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By Ding A.A., Wu H.

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Redefining the boost volume after 2 weeks of radiation therapy may help overcome this issue, but it is not clear if this is a valid strategy either. 56 This finding is consistent with data from the Danish Head and Neck Cancer Study Group57,58 although these studies did not rely exclusively on randomized treatment allocation. 59 Synthesizing all this evidence, 2 promising avenues for proliferation-targeting dose painting are being pursued. One is to assess the proliferative response to therapy rather than proliferation at baseline as a dose painting target.

Cancer 92:886-895, 2001 Aristei C, Falcinelli L, Palumbo B, et al: PET and PET-CT in radiation treatment planning for lung cancer. Expert Rev Anticancer Ther 10: 571-584, 2010 Grosu AL, Nestle U, Weber WA: How to use functional imaging information for radiotherapy planning. Eur J Cancer 45:461-463, 2009 (suppl 1) van Loon J, Offermann C, Bosmans G, et al: 18FDG-PET based radiation planning of mediastinal lymph nodes in limited disease small cell lung cancer changes radiotherapy fields: A planning study.

Grosu AL, Souvatzoglou M, Roper B, et al: Hypoxia imaging with FAZA-PET and theoretical considerations with regard to dose painting for individualization of radiotherapy in patients with head and neck cancer. Int J Radiat Oncol Biol Phys 69:541-551, 2007 52. Basu S, Alavi A: Molecular imaging (PET) of brain tumors. Neuroimaging Clin N Am 19:625-646, 2009 53. Wong TZ, Lacy JL, Petry NA, et al: PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator. AJR Am J Roentgenol 190:427-432, 2008 54.

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Assessing antiviral potency of anti-HIV therapies in vivo by comparing viral decay rates in viral dynamic models by Ding A.A., Wu H.

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