Adenoviruses: Model and Vectors in Virus-Host Interactions: - download pdf or read online

By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)

ISBN-10: 3642057152

ISBN-13: 9783642057151

ISBN-10: 3662055996

ISBN-13: 9783662055991

After 3 volumes on adenoviruses in 1995 the prior years have noticeable fast growth within the box of adenovirus study. furthermore, adenoviruses have attracted substantial curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity bargains with the immune process, oncogenesis and gene remedy.

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Additional info for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy

Sample text

TIP47 and PACS-l (Fig. 2) have been implicated in those pathways. TIP47 was recently shown to interact on endosomal membranes with Rab9-GTP, a protein which seems to regulate the generation of transport vesicles in endosomes destined for the TGN (Carroll et al. 2001). PACS-l forms ternary complexes with cargo proteins containing acidic clusters and AP-l or AP-3, but does not bind to AP-2. Overexpression of a dominant negative PACS-l mutant leads to a redistribution of furin and the cation-independent MPR (CI-MPR) from the TGN to a vesicular, most likely endosomal compartment, suggesting a role of PACS1 in endosome-TGN transport (Crump et al.

Clin. Invest. 105:1169-1172 Hitt MM, Graham FL (2000) Adenovirus vectors for human gene therapy. Advances in Virus Research, 55:479-505 Hosel M, Schroer J, Webb D, Jaroshevskaja E, Doerfler W (2001) Cellular and early viral factors in the interaction of adenovirus type 12 with hamster cells: the abortive response. Virus Research 81:1-16 Hou S, Guan H, Ricciardi RP (2002) In adenovirus type 12 tumorigenic cells, major histocompatibility complex Class 1 transcription shutoff is overcome by induction of NF-KB and relief of COUP-TFII repression.

J. 68:3917-3924 Jelinek T, Pereira DS, Graham FL (1994) Tumorigenicity of adenovirus-transformed rodent cells is influenced by at least two regions of adenovirus type 12 E1A. J Virol 68:888-896 Johnsen A, France J, Sy M-S, Harding CV (1998) Down-regulation of the transporter for antigen presentation, proteasome subunits and class I major histocompatibility complex in tumor cell lines. Cancer Res 58:3660-3667 Kafri T, Morgan D, Krahl T (1996) Cellular immune response against adenoviral infected cells does not require de novo viral gene expression: implications for gene therapy.

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Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy by G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)


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